I've ridden my Mandello s quite a bit now, and being an old superbike race tuner of course I couldn't just leave it alone.
The biggest improvement came from fitting Dunlop Roadsmart 4 tires, the steering feel is much lighter and more accurate, the bike "feels" 100 pounds lighter and of course there is now nearly track level grip.
I also addressed the heavy/full throttle flat spot in third gear before 5000 rpm where the throttle plates abruptly snap open. This is an issue caused by conforming to Euro5, many other Euro5 bikes have similar running quirks.
The fix is to remap using Upmap. Upmap is a phone app that talks to a "puck" plugged into the bike's communication port under the seat, it is simple and easy to use. I ditched the ten million pound (and ugly!) stock end can replacing it with an Agostini slipon with db killer in, it is just about as quiet yet dropped a bunch of weight.
Up map has a map for that configuration, along with about a dozen others. The result is perfectly civilized running, and maybe a touch more top end power. Maybe.
I also fitted the factory heated comfort seat and larger windscreen.
The thing that took the most time and effort was generating a personalized damping setting in "manual suspension 1" that I have designated for road mode. It is now firm yet plush with excellent handling.
Thus dialed in, it really is an excellent motorcycle.